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For the rat, the highest dose was, on a mg/m2 basis, about 2.5 the MRHD (Calculations based on a 60 kg patient)

This tripeptide was first identified in human plasma in the 1970s

The molecular mechanism involves the PI3K/AKT1 pathway, a major cell survival signaling cascade

2.6 Method validation The developed LC-MS/MS method for absolute quantification of Deg-AZM in biological samples was validated in accordance with the guidelines outlined in the Food and Drug Administration (FDA) Guidance for Industry on Bioanalytical Method Validation ( 2.7 Pharmacokinetic studies in rats and dogs Deg-AZM was administered to SD rats via a single intravenous bolus at the dose of 10 mg/kg or by single and multiple oral administration at the dose levels defined in each study